The blood-brain barrier (BBB) is a fundamental component of the central nervous system(CNS). Its functional and structural integrity is vital to maintain the homeostasis of the brain microenvironment by controlling the passage of substances and regulating the trafficking of immune cellsbetween the blood and the brain. The BBB is primarily composed of highly specialized microvascular […]
Both animal and human studies evaluating the role of gut dysbiosis on various neurological and neurosurgical diseases, published in peer-reviewed journals, were reviewed. Current studies do not provide conclusive evidence of a direct origin of CNS disorders from gut dysbiosis, but a possible modulatory role of gut microbiota in certain neurological disorders has been implicated.
Does modern research validate the ancient wisdom of gut flora and brain connection? Read More »
Communication between the GI tract and the CNS occurs via the neuronal,endocrine, and immunological pathways through a) the production of neurotransmitters, b) the tryptophan metabolism, c) the modulation of the immunological activity in the CNS and the SNE, d) production of short chain fatty acids, e) the production of intestinal hormones, and f) the production