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Mining imaging and clinical data with machine learning approaches for the diagnosis and early detection of Parkinson’s disease

Biomarkers, Non-Motor Symptoms, Parkinson's Disease, Pre-PD /

Parkinson’s disease (PD) is a common, progressive, and currently incurable neurodegenerative movement disorder. The diagnosis of PD is challenging, especially in the differential diagnosis of parkinsonism and in early PD detection. Due to the advantages of machine learning such as learning complex data patterns and making inferences for individuals, machine-learning techniques have been increasingly applied […]

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Therapeutics in the Pipeline Targeting α-Synuclein for Parkinson’s Disease

A-Synuclein, Dementia - Lewy Bodies, Parkinson's Disease /

Parkinson’s disease (PD) is the second most common neurodegenerative disorder and the fastest growing neurologic disease in the world, yet no disease-modifying therapy is available for this disabling condition. Multiple lines of evidence implicate the protein α-synuclein (α-Syn) in the pathogenesis of PD, and as such, there is intense interest in targeting α-Syn for potential disease modification. α-Syn

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Homeostatic regulation of neuronal excitability by probiotics in male germ-free mice

Gut-Brain axis, Parkinson's Disease, Probiotics, Prebiotics and Symbiotics /

Emerging evidence indicates that probiotics can influence the gut–brain axis to ameliorate somatic and behavioral symptoms associated with brain disorders. However, whether probiotics have effects on the electrophysiological activities of individual neurons in the brain has not been evaluated at a single-neuron resolution, and whether the neuronal effects of probiotics depend on the gut microbiome

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Trajectory Analysis of Orthostatic Hypotension in Parkinson’s Disease: Results From Parkinson’s Progression Markers Initiative Cohort

Biomarkers, Orthostatic Hypotension, Parkinson's Disease, Pre-PD /

This study provides new information on the longitudinal development of ΔSBP in patients with PD with distinct trajectories of rapidly increasing, low-stable, and high-stable class. Male sex, lower supine DBP, and lower total proteins helped to identify the class with increasing risk for OH. Further research is needed to discover the biological mechanisms that explain

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Porphyromonas gingivalis indirectly elicits intestinal inflammation by altering the gut microbiota and disrupting epithelial barrier function through IL9-producing CD4+ T cells

Gut Dysbiosis, Gut Microbiota, Oral Microbiome /

Background Recent epidemiological studies have shown that inflammatory bowel disease is associated with periodontal disease. The oral-gut microbiota axis is a potential mechanism intersecting the two diseases. Porphyromonas gingivalis is currently considered a keystone oral pathogen involved in periodontal disease pathogenesis and disease progression. Recent studies have shown that oral ingestion of P. gingivalis leads to intestinal inflammation. However,

Porphyromonas gingivalis indirectly elicits intestinal inflammation by altering the gut microbiota and disrupting epithelial barrier function through IL9-producing CD4+ T cells Read More »

Cognition and driving ability in isolated and symptomatic REM sleep behavior disorder

iRBD, Non-Motor Symptoms /

Study Objectives To analyze cognitive deficits leading to unsafe driving in patients with REM Sleep Behavior Disorder (RBD), strongly associated with cognitive impairment and synucleinopathy-related neurodegeneration.Methods Twenty isolated RBD (iRBD), 10 symptomatic RBD (sRBD), and 20 age- and education-matched controls participated in a prospective case-control driving simulation study. Group mean differences were compared with correlations

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Environmental triggers of Parkinson’s disease – Implications of the Braak and dual-hit hypotheses

A-Synuclein, Biomarkers, Gut Dysbiosis, Gut Permeability / Leaky Gut, Gut-Brain axis, Olfactory, Parkinson's Disease, Pre-PD /

Idiopathic Parkinson’s disease (PD) may take decades to develop, during which many risk or protective factors may come into play to initiate the pathogenesis or modify its progression to clinical PD. The lack of understanding of this prodromal phase of PD and the factors involved has been a major hurdle in the study of PD

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Gut Health Guide; Essential Oils Protocol

Gut Dysbiosis, Gut Permeability / Leaky Gut, Herbs & Spices, Parkinson's Disease /

IntroductionThere’s a reason we shorten the Standard American Diet to S-A-D. Never has amore fitting abbreviation been seen in the health industry. Our food, and theway our body processes that food, impacts our health in profound ways.And, it all starts in the gut.Put simply, when our gut isn’t healthy and happy, nothing about our bodies

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Digesting recent findings: gut alpha-synuclein, microbiome changes in Parkinson’s disease

A-Synuclein, Constipation, ENS, Gut Dysbiosis, Gut-Brain axis /

Two hallmarks of Parkinson’s disease (PD) are the widespread deposition of misfolded alpha-synuclein (αSyn) protein in the nervous system and loss of substantia nigra dopamine neurons. Recent research has suggested that αSyn aggregates in the enteric nervous system (ENS) lead to prodromal gastrointestinal (GI) symptoms such as constipation in PD, then propagating to the brain stem and eventually triggering neurodegeneration and

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What is leaky gut? Or… what? You can’t even eat HUMMUS?

Gut Dysbiosis, Gut Permeability / Leaky Gut, Parkinson's Disease, Pre-PD /

So what is intestinal permeability? Intestinal permeability (aka ‘leaky gut’) is the condition where the tight junctions on the lining of the intestine loosen, allowing undigested food particles, environmental toxins, foreign bacteria, and other normally restricted molecules to cross the gut barrier and migrate to other parts of the body. Normally, our intestines push molecules

What is leaky gut? Or… what? You can’t even eat HUMMUS? Read More »