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Attack of the Oligomers – Alpha-synuclein amyloid oligomers and their pathogenic roles

A-Synuclein, Parkinson's Disease /

In “Attack of the Oligomers,” we review how protein oligomersare the primary neurotoxic agents not just in Parkinson’s diseasebut also in Alzheimer’s (where they were discovered first) andother amyloid-related diseases. The oligomers wreak havocthroughout the cell, disrupting membranes and throwing proteinand ion homeostasis out of balance. However, the most criticaldamage in Parkinson’s disease seems to […]

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The Undeniable Link Between the Brain and Gut

Biomarkers, Constipation, Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Probiotics, Prebiotics and Symbiotics /

Nausea, heartburn, indigestion, constipation, andstomach pain are all kinds of gastrointestinal problems we have faced before. They are easy to dismissas merely an upset stomach, but this mentality couldbuild up and ultimately be detrimental to mental and physicalhealth. Improperly caring for the digestive system can lead toextensive intestinal health issues. The microbiome is a collectionof

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Does Data-Independent Acquisition Data Contain Hidden Gems? A Case Study Related to Alzheimer’s Disease

Autophagy, Parkinson's Disease /

One of the potential benefits of using data-independent acquisition (DIA) proteomics protocols is that information not originally targeted by the study may be present and discovered by subsequent analysis. Herein, we reanalyzed DIA data originally recorded for global proteomic analysis to look for isomerized peptides, which occur as a result of spontaneous chemical modifications to

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Protein Aggregation in the ER: Calm behind the Storm

A-Synuclein /

As one of the largest organelles in eukaryotic cells, the endoplasmic reticulum (ER) plays avital role in the synthesis, folding, and assembly of secretory and membrane proteins. To maintainits homeostasis, the ER is equipped with an elaborate network of protein folding chaperones andmultiple quality control pathways whose cooperative actions safeguard the fidelity of protein biogenesis.

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Orthostatic Hypotension: JACC State-of-the-Art Review

Autonmic nervous system, Non-Motor Symptoms, Orthostatic Hypotension, Parkinson's Disease, Pre-PD /

Neurogenic orthostatic hypotension is a highly prevalent and disabling feature of autonomic failure due to both peripheral and central neurodegenerative diseases. Community-based epidemiological studies have demonstrated a high morbidity and mortality associated with neurogenic orthostatic hypotension. It is due to impairment of baroreflex-mediated vasoconstriction of the skeletal muscle and splanchnic circulation and is caused by damage

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Psychedelic-Inspired Approaches for Treating Neurodegenerative Disorders

Ayahuasca, Parkinson's Disease, Pre-PD /

Psychedelics are increasingly being recognized for their potential to treat a wide range of braindisorders including depression, post-traumatic stress disorder (PTSD), and substance use disorder.Their broad therapeutic potential might result from an ability to rescue cortical atrophy common tomany neuropsychiatric and neurodegenerative diseases by impacting neurotrophic factor geneexpression, activating neuronal growth and survival mechanisms, and

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The gut connection: Intestinal permeability as a pathway from breast cancer survivors’ relationship satisfaction to inflammation across treatment

Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut /

The gut environment is a new promising candidate for understanding a relationship’s long-term health impact, particularly among those with elevated health risks. Survivors may reap multiple physiological benefits from satisfying relationships. CLICK TO REVIEW Keywords Cancer survivors, Gut microbiota, Inflammation Intestinal permeability Marriage Romantic relationships

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The Role of Dysbiosis in Neurological Disorders

Biomarkers, Butyrate, Fecal Transplants (FMT), Gut Dysbiosis, Gut Microbiota, Gut Permeability / Leaky Gut, Gut-Brain axis, Metabolites, Parkinson's Disease, Pre-PD, Probiotics, Prebiotics and Symbiotics, Short Chain Fatty Acids /

The gut brain axis is a system of bi-directional communication. When the delicate balance of the microbiome is disrupted, the resulting dysbiosis can be a factor in the development of neurological disorders, including Alzheimer’s Disease (AD), Parkinson’s Disease (PK), and Multiple Sclerosis (MS). One major player in the gut brain axis are short-chain fatty acids

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Dietary Plant Lectins Appear to Be Transported from the Gut to Gain Access to and Alter Dopaminergic Neurons of Caenorhabditis elegans, a Potential Etiology of Parkinson’s Disease

Gut-Brain axis, Lectins, Parkinson's Disease, Vagal Nerve /

Lectins from dietary plants have been shown to enhance drug absorption in the gastrointestinal tract of rats, be transported trans-synaptically as shown by tracing of axonal and dendritic paths, and enhance gene delivery. Other carbohydrate-binding protein toxins are known to traverse the gut intact in dogs. Post-feeding rhodamine- or TRITC-tagged dietary lectins, the lectins were

Dietary Plant Lectins Appear to Be Transported from the Gut to Gain Access to and Alter Dopaminergic Neurons of Caenorhabditis elegans, a Potential Etiology of Parkinson’s Disease Read More »

High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson’s disease

A-Synuclein, Biomarkers /

Alpha-synuclein seed amplification assays (αSyn-SAAs) are promising diagnostic tools for Parkinson’s disease (PD) and related synucleinopathies. They enable detection of seeding-competent alpha-synuclein aggregates in living patients and have shown high diagnostic accuracy in several PD and other synucleinopathy patient cohorts. However, there has been confusion about αSyn-SAAs for their methodology, nomenclature, and relative accuracies when

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