Collectively our data reported here is the first to provide evidence for a direct relationship between host energy metabolism at the proximal gut-microbiota interface and BP regulation. Further, our studies suggest that butyrate, which is a predominant colonic energy metabolite, contributes to the mechanism governing this relationship between energy metabolism in the proximal colon with […]
The gut microbiome appears to be predictive of Parkinson’s disease (PD) with constipation. Chronic constipation frequently manifests prior to motor symptoms and impairs quality of life. An osteopathic manipulative medicine (OMM) sequence used physical exam assessment and manual treatment of neuromusculoskeletal dysfunctions pertinent to constipation in PD for this prospective ABA-design study, IRB-NYITBHS1065. The effects
In recent years, emerging evidence suggests KD’s may also have therapeutic benefits for some cancers and for neurological conditions such asAlzheimer’s disease, Parkinson’s’ disease, multiple sclerosis, traumatic brain injury, and spinal cord injury. Finally, as the physiological mechanisms by which a KD operates become increasingly understood, we speculate that several other health conditions (e.g., autism,
Ketogenic Diet and Health Read More »
The proposed rehabilitation framework for iRBD includes early exercise-based interventions of aerobic exercise, progressive resistance training, and multimodal exercise with rehabilitation consultations to address exercise prescription, progression, and monitoring. This rehabilitation framework may be used to implement neuroprotective, multidisciplinary, and proactive clinical care in people with a high likelihood of conversion to PD, dementia with
Further experiments demonstrated that the beneficial effect of butyrate depended on the bacteria that colonized the gut and that this protective effect required SKN-1/Nrf2 and DAF-16/FOXO transcription factors. We also found that bacteria-derived protein aggregates contribute to the observed disruption of host proteostasis. Together, these results reveal the significance of enteric infection and gut dysbiosis
A strong association exists between lifestyle factors and AD prevalence wherein unhealthy dietary factors have been linked to neurodegeneration. Specific prudent dietary patterns might help in preventing or delaying AD progression by affecting β-amyloid production and tau processing and regulating AD-associated inflammation, metabolism and oxidative stress, plausibly via modulating gut microbiota. CLICK TO REVIEW
Diet-Microbiota-Brain Axis in Alzheimer’s Disease Read More »
The gut microbiome shifted among individuals with constipation and PD after four weekly treatments with the OMM-sequence. Changes in the gut microbiome Post-OMM were associated with UPDRS results and constipation measures. Clinical trials and studies to develop the gut microbiome into a validated biomarker for PD are necessary to understand the impact of OMM in
Thus, BEVs may be both a cause of and solution to neuropathological conditions. In this review, current knowledge of the physiological roles of BEVs as well as state of the art pertaining to the development of therapeutic BEVs in the context of the microbiome-gut-brain axis are summarized. CLICK TO REVIEW
As the profound interactions between the gut microbiota and the structure, chemistry, and activity of the brain continue to be discovered, the functional details of how the microbiota-gut-brain-axis works are starting to be resolved. Previous studies have suggested B. longum can cause changes in brain chemistry and activity [20]. Other research has revealed that modifications to expression of
Ingestion of Bifidobacterium longum changes miRNA levels in the brains of mice Read More »
Within this review, we will present a comprehensive overview of the data linking synuclein-associated Lewy pathology with intracellular dysfunction. We first present the alterations in neuronal proteins and transcriptome associated with LBs in postmortem human PD tissue. We next compare these findings to those associated with LB-like inclusions initiated by in vitro exposure to α-syn