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Research
Information is knowledge
Information is the most powerful tool in existance and it is my desire to share with our community everything I encounter on my journey to find a solution to Pre-PD and iRBD.
Alpha-synuclein oligomers and small nerve fiber pathology in skin are potential biomarkers of Parkinson’s diseas
The proximity ligation assay (PLA) is a specific and sensitive technique for the detection of αSyn oligomers (αSyn-PLA), early and
Gut Microbiota-Brain Interaction with Special Reference to Alzheimer’s Disease
Gut microbiota is showing and raising evidence that the dynamic changes in the gut microorganism can influence physiology and behavior
The link between the gut microbiota and Parkinson’s Disease: A systematic mechanism review with focus on α-synuclein transport
Research has suggested a link between the gut microbiota and Parkinson’s Disease (PD), and an early involvement of gastrointestinal dysfunction
Digesting recent findings: gut alpha-synuclein, microbiome changes in Parkinson’s disease
Two hallmarks of Parkinson’s disease (PD) are the widespread deposition of misfolded alpha-synuclein (αSyn) protein in the nervous system and
What is leaky gut? Or… what? You can’t even eat HUMMUS?
So what is intestinal permeability? Intestinal permeability (aka ‘leaky gut’) is the condition where the tight junctions on the lining
Effects of probiotic supplementation on intestinal tight junctions in a mouse model of Parkinson’s disease
Parkinson’s disease (PD) is a neurological disease impacting over six million people in the world. In addition to the motor
Attack of the Oligomers – Alpha-synuclein amyloid oligomers and their pathogenic roles
In “Attack of the Oligomers,” we review how protein oligomersare the primary neurotoxic agents not just in Parkinson’s diseasebut also
Parkinson disease: protective role and function of neuropeptides
Neuropeptides are bioactive molecules, made up of small chains of amino acids, with many neuromodulatory properties. Several lines of evidence
Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies
Several studies have confirmed α-synuclein real-time quaking-induced conversion (αSyn-RTQuIC) assay to have high sensitivity and specificity for Parkinson’s disease. However,
Glymphatic dysfunction in isolated REM sleep behavior disorder
The DTI-ALPS index was significantly lower in patients with iRBD than in healthy controls, indicating the presence of glymphatic-system dysfunction
REM sleep without atonia and vestibular-evoked myogenic potentials: Clinical brainstem dysfunction in early-stage Parkinson’s disease and isolated REM sleep behavior disorder
Brainstem neurophysiology as evidenced by altered VEMPs in patients with PD and iRBD could reflect disease evolvement. Moreover, VEMPs alterations
Nocturnal Teeth Grinding Linked With Incidence of Other Sleep-Related Disorders
SB is more prevalent in patients with the previously mentioned disorders than in the general population. Sleep arousal may be
Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease
Cellular quality control systems have gained much attention in recent decades. Amongthese, autophagy is a natural self-preservation mechanism that continuously
THE GUT-BRAIN AXIS: THE ROLE OF NUTRITION
The gut-brain axis (GBA) refers to the bi-directional communication thatoccurs between the gut and the brain. Recently, studies have highlightedthe
The gut microbiota-brain axis, psychobiotics and its influence on brain and behaviour: a systematic review
The gut microbiota is the set of microorganisms present in the gut, and it is connected to the central nervous system via the gut-brain
Correlations with REM sleep behavior disorder severity in isolated rapid eye movement sleep behavior disorders patients
Objectives: The pathogenesis of isolated rapid eye movement sleep behavior disorders (iRBD) is poorly understood. The severity of RBD may