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Research
Information is knowledge
Information is the most powerful tool in existance and it is my desire to share with our community everything I encounter on my journey to find a solution to Pre-PD and iRBD.
Bioactive lipids and their metabolism: new therapeutic opportunities for Parkinson’s disease
Parkinson’s disease (PD) is a neurological disorder characterized by motor dysfunction, which can also be associated with non-motor symptoms. Its
An experience with Holotropic Breathwork is associated with improvement in non-judgement and satisfaction with life while reducing symptoms of stress in a Czech-speaking population
Background Holotropic breathwork (Grof ® Breathwork), was developed by Stanislav Grof and Christina Grof as a ‘non-drug’ alternative technique to
S889 Effects of Etoh on Human Intestinal Epithelial and Microvascular Endothelial Cells (HIMEC) in Patients With Inflammatory Bowel Disease: An in-vitro Exploration
Ethanol (EtOH) is associated with IBD flares, but the exact mechanisms are not well-known. Gut dysbiosis and depleted luminal butyrate
α-Synuclein aggregation in the olfactory bulb induces olfactory deficits by perturbing granule cells and granular–mitral synaptic transmission
Olfactory dysfunction is an early pre-motor symptom of Parkinson’s disease (PD) but the neural mechanisms underlying this dysfunction remain largely
Modeling approaches for probing cross-feeding interactions in the human gut microbiome
Microbial communities perform emergent activities that are essentially different from those carried by their individual members. The gut microbiome and its metabolites
Neuroprotection of chicoric acid in a mouse model of Parkinson’s disease involves gut microbiota and TLR4 signaling pathway
Chicoric acid (CA), a polyphenolic acid obtained from chicory and purple coneflower (Echinacea purpurea), has been regarded as nutraceutical to
Sodium butyrate attenuates rotenone-induced toxicity by activation of autophagy through epigenetically regulating PGC-1α expression in PC12 cells
Short-chain fatty acids (SCFAs) are considered the key molecular link between gut microbiota and pathogenesis of Parkinson’s disease (PD). However,
Brain-derived Neurotrophic Factor and Its Applications through Nanosystem Delivery
Brain-derived neurotrophic factor (BDNF) is a protein that performs a neurotrophic function.BDNF and its receptors are widely expressed in the
Regulation of common neurological disorders by gut microbial metabolites
The gut is connected to the CNS by immunological mediators, lymphocytes, neurotransmitters, microbes and microbial metabolites. A mounting body of
The role of probiotics in nutritional health: probiotics as nutribiotics
The gut microbiota has gained importance through the years due to its significant influences on the maintenance of human health.
Deep nasal sinus cavity microbiota dysbiosis in Parkinson’s disease
Olfactory dysfunction is a pre-motor symptom of Parkinson’s disease (PD) that appears years prior to diagnosis and can affect quality
The Undeniable Link Between the Brain and Gut
Nausea, heartburn, indigestion, constipation, andstomach pain are all kinds of gastrointestinal problems we have faced before. They are easy to
Potential Role of Akkermansia muciniphila in Parkinson’s Disease and Other Neurological/Autoimmune Diseases
The composition of the gut microbiota, including Akkermansia muciniphila (A. muciniphila), is altered in many neurological diseases and may be involved in
Gram-negative bacteria and their lipopolysaccharides in Alzheimer’s disease: pathologic roles and therapeutic implications
Alzheimer’s disease (AD) is the most serious age-related neurodegenerative disease and causes destructive and irreversible cognitive decline. Failures in the
Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle
The human microbiota comprises trillions of symbiotic microorganisms and is involved in regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis. Recent
Does Data-Independent Acquisition Data Contain Hidden Gems? A Case Study Related to Alzheimer’s Disease
One of the potential benefits of using data-independent acquisition (DIA) proteomics protocols is that information not originally targeted by the