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Research
Information is knowledge
Information is the most powerful tool in existance and it is my desire to share with our community everything I encounter on my journey to find a solution to Pre-PD and iRBD.
Mitochondrial Dysfunction, Protein Misfolding and Neuroinflammation in Parkinson’s Disease: Roads to Biomarker Discovery
Parkinson’s Disease (PD) is a highly prevalent neurodegenerative disease among olderadults. PD neuropathology is marked by the progressive loss of
What Substance P might tell us about the Prognosis and Mechanism of Parkinson’s Disease?
The neuropeptide substance P (SP) plays an important role in neurodegenerative disorders, among which Parkinson’s disease (PD). In the present
Gut Microbiome and Alzheimer’s Disease
The lack of an effective treatment for Alzheimer’s disease (AD) stems primarily from incomplete understanding of AD’s causes. A rapidly
The pathogenic mechanism of oral bacteria and treatment with inhibitors
Objectives: The objective of this study was to introduce the evidence obtained throughextensive research that periodontitis increases risk of many
PROTECTIVE ROLE OF THE FLANKING DOMAINS AND MEMBRANE SELECTIVITY IN THE ALPHA-SYNUCLEIN
Alpha-synuclein protein is associated with Parkinson’s disease and is an intrinsically disordered protein (IDP) in solution. The protein consists of
Neurodegenerative
Over the past decades, any attempt at identifying a single, curative treatment for neurodegenerative conditions has failed. For example, over
Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer’s disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis
According to recent evidence, psychobiotics exert beneficial effects on central nervous system-related diseases, such as mental disorders. Lactobacillus plantarum PS128 (PS128), a
Alkaloids of Peganum harmala L. and their Pharmacological Activity
The presented data of preclinical studies showed that harmine hydrochloride has antidepressant,antihypoxic, and antiparkinsonian effects, eliminates catalepsy caused by haloperidol
Overcoming epistemic injustices in the biomedical study of ayahuasca. Towards ethical and sustainable regulation
After decades of biomedical research on ayahuasca’s molecular compounds and theirphysiological effects, recent clinical trials show evidence of therapeutic potential
A novel multi-target strategy to attenuate the progression of Parkinson’s disease by diamine hybrid AGE/ALE inhibitor
Instead of a conventional ‘one-drug-one-target approach’, this article presents a novel multi-target approach with a concept of trapping simultaneously as
Genome-wide association study of REM sleep behavior disorder identifies novel loci with distinct polygenic and brain expression effects
Rapid eye movement (REM) sleep behavior disorder (RBD), enactment of dreams during REM sleep, isan early clinical symptom of alpha-synucleinopathies.
Neurotoxins that cause parkinsonism and the search for analogues in the environment
Through the tragic misadventures described in Addicts,the parkinsonism-inducing neurotoxin 1-methyl-4-phenyl1,2,3,6-tetrahydropyridine (MPTP) was discovered. It hasbeen one of the most important
Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion
Emerging evidence is revealing that alterations in gut microbiota are associated with colorectal cancer (CRC). However, very little is currently
Circulatory 25(OH)D and 1,25(OH)2D as differential biomarkers between multiple system atrophy and Parkinson’s disease patients
There is sufficient evidence to support vitamin D’s noncalcemic effects and the role ofvitamin D deficiency in the development of
Mild Parkinsonian Signs: A Systematic Review of Clinical, Imaging, and Pathological Associations
There are currently no consistent radiological findings for MPS, and pathological studies have shown that MPS, at least in the
Mitochondrial Dysfunction in a Mouse Model of Prodromal Parkinson’s Disease: A Metabolomic Analysis
For the development of disease-modifying therapies for Parkinson’s disease (PD) the identification of biomarkers in the prodromal stage is urgently