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Research
Information is knowledge
Information is the most powerful tool in existance and it is my desire to share with our community everything I encounter on my journey to find a solution to Pre-PD and iRBD.
Calcium channels and iron metabolism: A redox catastrophe in Parkinson’s disease and an innovative path to novel therapies?
Autonomously spiking dopaminergic neurons of the substantia nigra pars compacta (SNpc) are exquisitely specialized and suffer toxic iron-loading in Parkinson’s
Advances in early predictors for phenotypic transformation of idiopathic rapid eye movement sleep behavior disorder
Idiopathic rapid eye movement (REM) sleep behavior disorder is recognized as a prodromal stage of α-synucleinopathies such as Parkinson′s disease, Lewy body dementia and multiple system atrophy. It is important to timely
Heat Shock Proteins, Sauna, and Global Health Benefits
What are Heat Shock Proteins? When cells are exposed to stressful situations, they respond by creating heat shock proteins. Since
Heat Shock Protein 70 as a Sex-Skewed Regulator of α-Synucleinopathy
The role of molecular chaperones, such as heat shock protein 70 (Hsp70), is not typically studied as a function of
Parkinson’s disease outside the brain: targeting the autonomic nervous system
Patients with Parkinson’s disease present with signs and symptoms of dysregulation of the peripheral autonomic nervous system that can even
Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle
The human microbiota comprises trillions of symbiotic microorganisms and is involved in regulating gastrointestinal (GI), immune, nervous system and metabolic
Recent aspects of ketogenic diet in neurological disorders
The ketogenic diet (KD) is a high-fat, low-carbohydrate diet, in which fat is used as the primary energy sourcethrough the
Genome-wide association study of REM sleep behavior disorder identifies novel loci with distinct polygenic and brain expression effects
Rapid eye movement (REM) sleep behavior disorder (RBD), enactment of dreams during REM sleep, isan early clinical symptom of alpha-synucleinopathies.
Investigating Casual Associations among Gut Microbiota, Metabolites and Neurodegenerative Diseases: A Mendelian Randomization Study
Our study firstly applied a two-sample MR approach to detect causal relationships among gut microbiota, gut metabolites and the risk
The Effect of a Probiotic Complex on the Gut-Brain Axis: A Translational Study
A significant improvement of cognitive functions, in terms of short-termmemory, attention, and executive performance, as well as ofpsychophysiological markers, such
A New Kind of Pathogen – The prion-like pathology of amyloid fibrils in Parkinson’s disease
This chapter contrasts the prion-like behavior of alphasynuclein in Parkinson’s disease with other prion diseases.In prion diseases, the infectious, amyloid
The effects of coffee consumption and antibiotic use on gut microbial community structure of Parkinson’s disease patients
Parkinson’s disease (PD) is a complex brain disorder involving a multitude ofcontributing factors ranging from environmental to genetic. Interestingly, it
The Effects of Intermittent Fasting on Brain and Cognitive Function
The importance of diet and the gut-brain axis for brain health and cognitive function isincreasingly acknowledged. Dietary interventions are tested
Epigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease
The gastrointestinal tract may be a site of origin for α-synuclein pathology in idiopathic Parkinson’s disease (PD). Disruption of the
The effect of oral butyrate administration on the release of serotonin and dopamine in the gastrointestinal trac
The microbiota-gut-brain axis is a modern concept with wide and physiologically important effects.The aim of the study was to investigate
Lactiplantibacillus plantarum PS128 Alleviates Exaggerated Cortical Beta Oscillations and Motor Deficits in the 6-Hydroxydopamine Rat Model of Parkinson’s Disease
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by midbrain dopaminergic neuronal loss and subsequent physical impairments. Levodopa manages symptoms