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Research
Information is knowledge
Information is the most powerful tool in existance and it is my desire to share with our community everything I encounter on my journey to find a solution to Pre-PD and iRBD.
Sauna use as a lifestyle practice to extend healthspan
Sauna use, sometimes referred to as “sauna bathing,” is characterized by short-term passive exposure to high temperatures, typically ranging from
Parkinson’s disease risk genes act in glia to control neuronal α-synuclein toxicity
We identified 4 modifiers: aux, Lrrk, Ric, and Vps13, orthologs of the human genes GAK, LRRK2, RIT2, and VPS13C, respectively. Knockdown of each gene exacerbated neurodegeneration
Multimodal retinal imaging to detect and understand Alzheimer’s and Parkinson’s disease
Retinal neurodegeneration and visual dysfunctions have been reported in a majority of Alzheimer’s and Parkinson’s patients, and, in light of the quest for novel
Vitamin C Supplementation in Healthy Individuals Leads to Shifts of Bacterial Populations in the Gut—A Pilot Study
Daily supplementation of high-dose vitamin C led to an increase in the relative abundances of Lachnospiraceae (p < 0.05), whereas
A blood marker for Parkinson’s Disease: Neuronal exosome-derived α-synuclein
To date, no reliable clinically applicable biomarker has been established for Parkinson’s disease (PD). Our results indicate that a long
Quercetin Prevents Oxidative Stress-Induced Injury of Periodontal Ligament Cells and Alveolar Bone Loss in Periodontists
In conclusion, the present study revealed that quercetin ameliorated the oxidative damage and improved the antioxidative ability of PDLCs by
Parkinson’s disease patients’ short chain fatty acids production capacity after in vitro fecal fiber fermentation
Short-chain fatty acid production was analyzed by headspace solid-phase micro-extraction gas chromatography-mass spectrometry. Clostridium coccoides and C. leptum were quantified through 16S-rRNA gene-targeted group-specific
Genetic and environmental factors in Alzheimer’s and Parkinson’s diseases and promising therapeutic intervention via fecal microbiota transplantation
The gut microbiota provides potential therapeutic targets that can be regulated as new interventions for neurodegenerative diseases. In this review,
Gut brain axis: an insight into microbiota role in Parkinson’s disease
The gut-brain axis is a two-way communication system, which explains how through the vagus nerve, the gut microbiota can affect
Alterations in the gut microbiota contribute to cognitive impairment induced by the ketogenic diet and hypoxia
Here, we show that a carbohydrate-restricted (ketogenic) diet potentiates CI induced by intermittent hypoxia in mice and alters the gut microbiota.
Fecal Microbiota Transplantation Exerts a Protective Role in MPTP-Induced Parkinson’s Disease via the TLR4/PI3K/AKT/NF-κB Pathway Stimulated by α-Synuclein
A mouse model with PD was established via injection of MPTP. Normal or MPTP-induced PD like animals were treated with
Neurogenic and anti-inflammatory effects of probiotics in Parkinson’s 3 disease: a systematic review of preclinical and clinical evidence
Findings from preclinical studies suggest that treatment with probiotics increased glucose metabolism (increased secretion of glucagon-like peptide-1), reduced peripheral and
Pursuing Multiple Biomarkers for Early Idiopathic Parkinson’s Disease Diagnosis
Currently, there is no objective molecular or biochemical test for PD; its diagnosis is based on clinical criteria, mainly by
Oral Dysbiosis and Alzheimer’s Disease Risk
The oral microbiome is implicated in many systemic illnesses such as cardiovascular disease, metabolic syndrome, respiratory infections, and cognitive decline,
Dietary intake and plasma levels of polyunsaturated fatty acids in early-stage Parkinson’s disease
In a case–control study with 38 patients with PD and 33 controls, we assessed dietary intake using food frequency questionnaires
Boxing vs Sensory Exercise for Parkinson’s Disease: A Double-Blinded Randomized Controlled Trial
A significant interaction effect between groups and time were observed F(1, 39) = 4.566, P = .036, where the sensory