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Research
Information is knowledge
Information is the most powerful tool in existance and it is my desire to share with our community everything I encounter on my journey to find a solution to Pre-PD and iRBD.
Extracellular Vesicles as Novel Diagnostic and Prognostic Biomarkers for Parkinson’s Disease
Brain-derived EVs are able to cross the blood-brain barrier,protecting their payload from enzymatic degradation, and are easily recovered from biofluids.
The Baseline Structure of the Enteric Nervous System and Its Role in Parkinson’s Disease
The present manuscript is dedicated to identifying various neuronal cytotypes belonging to ENS in baseline conditions. The second part ofthe
Interactions between the microbiota and enteric nervous system during gut-brain disorders
The ENS, which is known as the “second brain”, could be under the direct or indirect influence of the gut
Olfactory dysfunction in aging and neurodegenerative diseases
The establishment of biomarkers that promote early risk identification is critical for the implementation of early treatment to postpone or
Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder
Patients with isolated rapid-eye-movement sleep behaviour disorder (RBD) are commonly regarded as being in the early stages of a progressive neurodegenerative
Inflammatory Bowel Disease, Alpha-Synuclein Aggregates and Parkinson’s Disease: The InflamaSPark Protocol
The hallmark of Parkinson’s disease (PD) is the accumulation of alpha-synuclein (AS) aggregates. Prior to the central nervous system involvement,
New Psychedelic Therapy AKO004 Under Development by Akome
Psychedelics such as DMT are strong substances that can change perception, mood, and cognitive processes. DMT produces its intense hallucinations by triggering
REM Sleep Behavior Disorder as a Pathway to Dementia: If, When, How, What, and Why Should Physicians Disclose the Diagnosis and Risk for Dementia
We provide an approach to risk disclosure for patients with iRBD. Patients should be asked if they want to know
The Baseline Structure of the Enteric Nervous System and Its Role in Parkinson’s Disease
The second part ofthe study provides evidence on how these very same neurons are altered during Parkinson’s disease.In fact, although
Parkinson’s disease and periodontitis – the missing link? A review
We cannot cure Parkinson’s disease, but if in future this missing link is established, an attempt can be made to
Is There Any Association Between Neurodegenerative Diseases and Periodontitis? A Systematic Review
All the included studies reported higher levels of inflammatory markers, IgG levels of periodontal bacteria, and/or clinical parameters of periodontitis
Temporal trajectory of biofluid markers in Parkinson’s disease
At baseline, PD patients showed lower CSF α-syn, Aβ, t-tau and p-tau levels than those of the controls. In all
Neuroprotective effect of Lactobacillus plantarum DP189 on MPTP-induced Parkinson’s disease model mice
The results indicated that L. plantarum DP189 improved behavioral ability and increased the levels of 5-hydroxytryptamine and dopamine of PD mice. L. plantarum DP189
Fecal Microbiota Transplantation: A Microbiome Modulation Technique for Alzheimer’s Disease
Microbiota-targeted interventions such as personalized diet, probiotics, or fecal microbiota transplantation (FMT) might represent a potential therapeutic option for AD.
IMPACT OF THE SHORT – CHAIN FATTY ACIDS ON THE MICROBIOTA – GUT – BRAIN AXIS
Studies show that short – chain fatty acids have differenteffects by increasing or decreasing the quantity of certain molecules such
Probiotics and the Treatment of Parkinson’s Disease: An Update
Probiotic supplementation mediates these pharmacological effects by targeting a variety of cellular and molecular processes, i.e., oxidative stress, inflammatory and