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Research
Information is knowledge
Information is the most powerful tool in existance and it is my desire to share with our community everything I encounter on my journey to find a solution to Pre-PD and iRBD.
The gut microbiome: implications for neurogenesis and neurological diseases
The gut microbiome has also gained increasing attention in PD, and its involvement has been strongly implicated in the modulation
α-Synuclein Deposition in Sympathetic Nerve Fibers in Genetic Forms of Parkinson’s Disease
Individuals with SNCA, DJ-1, LRRK2, or GBA mutations have substantial intraneuronal α-syn deposition in sympathetic noradrenergic nerves in skin biopsies, whereas those with biallelic PRKN mutations do
Deciphering and manipulating the epigenome for the treatment of Parkinson’s and Alzheimer’s disease
This narrative review aimed to elaborate on the potential epigenomic treatments for PD and AD. About 199 scientific articles written
Identification of leaky gut-related markers as indicators of metabolic health in Dutch adults: The Nutrition Questionnaires plus (NQplus) study
Biomarkers that link a leaky gut and subsequent bacterial translocation to metabolic health were identified in this study. Especially zonulin
Retinal thickness and microvascular pathway in Idiopathic Rapid eye movement sleep Behaviour Disorder and Parkinson’s disease
In PD and iRBD patients retina was thinner than HCs, and values of iRBD were between PD and HCs. Moreover,
Dietary bioactive compounds as modulators of mitochondrial function
In the last years, it has been consistently reported that the modulation of mitochondrial function represents one of the mechanisms
Design of synthetic human gut microbiome assembly and butyrate production
Guided by the model, we identify constraints on butyrate production by high species richness and key molecular factors driving butyrate
MIND and Mediterranean Diets Associated with Later Onset of Parkinson’s Disease
This cross-sectional study found a strong correlation between age of onset of PD and dietary habits, suggesting that nutritional strategies
Clinical Markers May Identify Patients at Risk for Early Parkinson’s Disease Dementia: A Prospective Study
Patients with signs of autonomic dysfunction and insomnia are at higher risk for developing dementia and deserve closer monitoring of
The Potential Role of Cinnamon in Human Health
In folk medicine, cinnamon species have been used as medicine for respiratory and digestive disorders. Their potential for prophylactic and
Motor Dysfunction in REM Sleep Behavior Disorder: A Rehabilitation Framework for Prodromal Synucleinopathy
The proposed rehabilitation framework for iRBD includes early exercise-based interventions of aerobic exercise, progressive resistance training, and multimodal exercise with
Serum metabolic biomarkers for synucleinopathy conversion in isolated REM sleep behavior disorder
Our results indicate that metabolic alterations and inflammation are involved in iRBD pathophysiology, and suggest biological differences underlying the progression
Neurological disorders associated with impaired gut microbiota
Proinflammatory mediators such as iNOS, ROS, COX2 and NF-B are released by microglia, resulting in neuroinflammation in Alzheimer’s disease. It
Supplementation of regular diet with medium-chain triglycerides for neuroprotective effects
This review summarizes currently available research on the effects and revealed mechanisms of using MCTs as a supplement to standard
Investigating Causal Relations Between Circulating Metabolites and Alzheimer’s Diseases: a Mendelian Randomization Study
Our findings provided robust evidence supporting causal effects of circulating glycoprotein acetyls, ApoB, LDL cholesterol, and serum total cholesterol on
Role of microbiota-derived short-chain fatty acids in nervous system disorders
It has been noted remodeling in the gut microbiota metabolites associated with the pathophysiology of several neurological disorders, such as Alzheimer’s disease, multiple sclerosis, Parkinson’s disease, amyotrophic lateral sclerosis,