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Research
Information is knowledge
Information is the most powerful tool in existance and it is my desire to share with our community everything I encounter on my journey to find a solution to Pre-PD and iRBD.
Voice for Health: The Use of Vocal Biomarkers from Research to Clinical Practice
Diseases can affect organs such as the heart, lungs, brain, muscles, or vocal folds, which can then alter an individual’s
The α-Synuclein Origin and Connectome Model (SOC Model) of Parkinson’s Disease: Explaining Motor Asymmetry, Non-Motor Phenotypes, and Cognitive Decline
Consequently, the initial α-synuclein pathology inside the CNS is more symmetric, which promotes more symmetric propagation in the brainstem, leading
Elucidating the Multi‐Targeted Role of Nutraceuticals: A Complementary Therapy to Starve Neurodegenerative Diseases
The current review summarizes the popular nutraceuticals showing different effects (anti‐inflammatory, antioxidant, neuro‐protectant, mitochondrial homeostasis, neurogenesis promotion,and autophagy regulation) on
Bacterial Extracellular Vesicles and the Gut-Microbiota Brain Axis: Emerging Roles in Communication and Potential as Therapeutics
Thus, BEVs may be both a cause of and solution to neuropathological conditions. In this review, current knowledge of the
Ingestion of Bifidobacterium longum changes miRNA levels in the brains of mice
As the profound interactions between the gut microbiota and the structure, chemistry, and activity of the brain continue to be
Probiotic Properties and Immunomodulatory Activity of Lactobacillus Strains Isolated from Dairy Products
Studies of the gut microbiota on health and disease are of high importance, and the role of probiotics and prebiotics
Association of small intestinal bacterial overgrowth with Parkinson’s disease: a systematic review and meta-analysis
Our meta-analysis identified a strong association between SIBO and PD with approximately half of PD patients testing positive for SIBO.
Speech biomarkers in rapid eye movement sleep behaviour disorder and Parkinson’s disease.
Automated speech analysis may provide a useful additional biomarker of parkinsonism for the assessment of disease progression and therapeutic interventions.
The role of gut dysbiosis in Parkinson’s disease: mechanistic insights andtherapeutic options
We highlight recent discoveries and alterations of the gut microbiota in Parkinson’s disease, and highlight current mechanistic insights on the
Nonmotor symptom burden grading as predictor of cognitive impairment in Parkinson’s disease
Our findings suggest that a comprehensive baseline measure of NMS and in particular hallucinations and perceptual problems assessed with a
Alpha-synuclein seeds in olfactory mucosa of patients with isolated REM sleep behaviour disorder
We provide evidence that the α-synuclein RT-QuIC assay enables the molecular detection of neuronal α-synuclein aggregates in olfactory mucosa of
Consistent skin α-synuclein positivity in REM sleep behavior disorder – a two center two-to-four-year follow-up study
Dermal p-syn in iRBD is most probably an early consistent marker of synucleinopathy and may support other indicators of conversion
Synucleinopathy-associated pathogenesis in Parkinson’s disease and the potential for brain-derived neurotrophic factor
Within this review, we will present a comprehensive overview of the data linking synuclein-associated Lewy pathology with intracellular dysfunction. We
Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids
This review specifically highlights the regulatory functions of DF and SCFAs in the immune system with a focus on major
Dietary restrictions modulate the gut microbiota: Implications for health and disease
The data suggest that changing the gut microbiota composition by dietary restriction has the potential to positively influence the progression
Microbiota-derived short chain fatty acids modulate microglia and promote Ab plaque deposition
Despite increased microglial recruitment to Ab plaques upon SCFA supplementation, microglia contained less intracellular Ab. Taken together, our results demonstrate