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Research
Information is knowledge
Information is the most powerful tool in existance and it is my desire to share with our community everything I encounter on my journey to find a solution to Pre-PD and iRBD.
Delayed orthostatic hypotension in Parkinson’s disease
Linear trends across the pre-ordered OH subtypes found that clinical parameters worsened along with the orthostatic challenge. Clinical scales deteriorated
Association of Sleepwalking and REM Sleep Behavior Disorder With Parkinson Disease in Men
In this cross-sectional study of a male population, probable sleep parasomnias, including both SW and RBD, were associated with higher
Intermittent metabolic switching, neuroplasticity and brain health
Here, we consider how intermittent metabolic switching, repeating cycles of a metabolic challenge that induces ketosis (fasting and/or exercise) followed
Dual Roles of Microglia in the Basal Ganglia in Parkinson’s Disease
The activated microglia then eliminate the hyperactive glutamatergic synapses. Synapse elimination may be the mechanism underlying the compensation that masks
Gut-brain axis and immunoneuroendocrine modulation in neurological and psychiatric disorders: Asystematic review
Communication between the GI tract and the CNS occurs via the neuronal,endocrine, and immunological pathways through a) the production of
Natural polyphenols in central nervous system disorders
Reduced oxidative stress causes the suppression of the risk of associated neurodegenerative diseases, such as, Alzheimer’s disease (AD), stroke, multiple
Biochemical Markers in the Urine Associated with Gastrointestinal Mold-Overgrowth Are Linked with Elevated Urinary Mycotoxins in Patients with Suspected Mold Illness
Exposure to mycotoxins can lead to acute as well as chronic toxic effects, which are dependent on the mycotoxin type,
Alpha-synuclein induces progressive changes in brain microstructure and sensory-evoked brain function that precedes locomotor decline.
At 12 weeks post-injection, a separate 43 and distinct pattern of structural and sensory-evoked functional brain activity changes was 44
Functional imaging of the brainstem during visually-guided motor control reveals visuomotor regions in the pons and midbrain
Visuomotor activity during visually-guided pinch-grip force was measured while controlling for force without visual feedback activity and visual stimuli without
Parkinsonism and Related Disorders Electrogastrography for diagnosis of early-stage Parkinson’s disease
Early and untreated PD patients showed irregular EGG waves and high ICDF. EGG showed better accuracy than the olfactory test
Toward Precision Medicine: Effects of the Common VAL66met BDNF Variant in the Aging Brain and Implications for the Future of Parkinson’S Disease Therapeutics
In this rapidly evolving era of precision medicine, understanding mechanisms underlying the beneficial versus detrimental impact of the Val66Metpolymorphism, and/or
Metals associated neurodegeneration in Parkinson’s disease: Insight to physiological, pathological mechanisms and management
There is increasing evidence that heavy metals normally present in the human body in minute concentration also cause accumulation to
Short chain fatty acids and its producing organisms: An overlooked therapy for IBD?
This review provides an overview of the current knowledge of these effects, with specific focus on energy metabolism, intestinal barrier,
Source of gut microbiota determines oat β-glucan degradation and short chain fatty acid-producing pathway
Overall, our data suggested that β-glucan could be completely hydrolyzed by human fecal microbiota but not thoroughly degraded by mice fecal
Complications following REM sleep behavior disorder
REM sleep behavior disorder (RBD) is gaining increasing attention as important prodromal marker for the development of neurodegenerative disorders such
The gut-brain connection in the pathogenicity of Parkinson disease: Putative role of autophagy
Hence, this review will mainly focus on analysing the basic components of the gut that might be responsible for aggravating