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Information is the most powerful tool in existance and it is my desire to share with our community everything I encounter on my journey to find a solution to Pre-PD and iRBD.
3-Hydroxybutyrate as a Metabolite and a Signal Molecule
Regulating Processes of Living Organisms
. Additionally, in animals, 3-HB is not only an intermediate metabolite, but also an important regulatory molecule that can influence
Natural antioxidants in the management of Parkinson’s disease: review of evidence from cell line and animal models
Therefore, the use of natural antioxidants in PD may provide an alternative therapy that prevents oxidative stress and reduces disease
Multi-strain probiotics (Hexbio) containing MCP BCMC strains improved constipation and gut motility in Parkinson’s disease
This study showed that consumption of a multi-strain probiotic (Hexbio®) over 8 weeks improved bowel opening frequency and whole gut
Unravelling the potential of gut microbiota in sustaining brain health and their current prospective towards development of neurotherapeutics
Reports also showed that colonization of gut microbiota isolated from patients suffering from neurodegenerative disease leads to the development of
Investigating the Putative Mechanisms Mediating the Beneficial Effects of Exercise on the Brain and Cognitive Functions
A variety of brain disorders including alzheimer’s disease, parkinson’s disease, chronic stress, age-related cognitive decline, psychological disorders have been revealed
Alpha-synuclein preformed fibrils: a tool to understand Parkinson’s disease and develop disease modifying therapy
Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized by multiple motor and non-motor symptoms, which include, among
Inflaming the Brain with Iron
In this review, we will summarize findings that connect neuroinflammation and iron accumulation, which support their causal association in the
microRNA signatures in prodromal REM sleep behavior disorder and early Parkinson’s disease as noninvasive biomarkers
The damage may start at an early period of brain degeneration, in the non-motor or “prodromal” stage, where autonomic, mood
Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates
. This study does not support the hypothesis of a transmission of a-synuclein pathology through the vagus nerve and the
Iron Dysregulation and Inflammagens Related to Oral and Gut Health Are Central to the Development of Parkinson’s Disease
We argue that there is significant evidence that bacterial inflammagens fuel this systemic inflammation, and might be central to thedevelopment
Fecal microbiota transplantation ameliorates gut microbiota imbalance and intestinal barrier damage in rats with stress‐induced depressive‐like behavior
The gut‐microbiota‐brain axis is the most important complex and bidirectional pathway between the gastrointestinal tract and the central nervous system.
Herbal medicine WangShiBaoChiWan improves gastrointestinal health in mice via modulation of intestinal tight junctions and gut microbiota and inhibition of inflammation
WSBCW upregulated intestinal junction proteins, increased the abundance of Bifidobacterium genus, Desulfovibrio genus and inhibited Bacteroides fragillis group in the gut microbiota, increased intestinal
Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson’s disease
In human post-mortem liver tissue, we identifed cases with neuropathologically confrmed α-syn pathology containing α-syn within hepatocellular structures to a
Effects of niacin on intestinal immunity, microbial community and intestinal barrier in weaned piglets during starvation
In conclusion, niacin attenuated the weight loss and diarrhea, and improved the expression of antimicrobial peptides, and enhanced intestinal epithelial
Effect of 8-Day Fasting on Leukocytes Expression of Genes and Proteins Involved in Iron Metabolism in Healthy Men
Eight days of total starvation diet affected the body composition and decreased exercise capacity. Further, fasting decreased the expression of
Cell specific quantitative iron mapping on brain slices by immuno-µPIXE in healthy elderly and Parkinson’s disease
The highest cellular iron levels in neurons were located in the cytoplasm, which might increase the source of non-chelated Fe3+,