library
Research
Information is knowledge
Information is the most powerful tool in existance and it is my desire to share with our community everything I encounter on my journey to find a solution to Pre-PD and iRBD.
The cell biology of Parkinson’s disease
Parkinson’s disease (PD) is a progressive neurodegenerative disorder resulting from the death of dopamine neurons in the substantia nigra pars
Biomarkers and the Role of α-Synuclein in Parkinson’s Disease
This review article aims to summarize useful biomarkers for the diagnosis of PD, as well as the biomarkers used to
Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis
These findings suggest that varieties in dietary patterns result in the production of diverse microbial fermentation metabolites, which contribute to
Dietary restrictions modulate the gut microbiota: Implications for health and disease
The data suggests that changing the gut microbiota composition by dietary restriction has the potential to positively influence the progression
Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration in Drosophila
Taken together, our results presented here indicate α-syn accumulation in presynaptic terminals affects synaptic proteins and active zone integrity that
A Goal Intervention Improves Language Fluency: Evidence from Parkinson’s Disease and Healthy Aging
The goal intervention was effective for PD patients and older adults, suggesting that enhanced goal specificity and difficulty may benefit
Nutritional aspects in Parkinson’s disease
The links between diet and Parkinson’s disease (PD) are unclear and incomprehensible. However, numerous studies have demonstrated the correlation between
PPMI 2.0 Clinical -Establishing a Deeply Phenotyped PD Cohort (PPMI)
The Parkinson Progression Marker Initiative 2.0 (PPMI 2.0) is a longitudinal, observational, multi-center natural history study to assess progression of
An Overview of Alpha Synuclein Protein and Its Role in Parkinson’s disease
Under pathologic conditions, cellular accumulation of misfolded α-synuclein oligomers and aggregates are observed in a group of neurodegenerative diseases called
The gut microbiota metabolite propionate ameliorates intestinal epithelial barrier dysfunction-mediated Parkinson’s disease via the AKT signaling pathway
Our results demonstrated that propionate, which was decreased in the fecal samples of Parkinson’s disease patients, exerted beneficial effects on intestinal
Autonomic disorders predicting Parkinson disease
There is evidence that constipation, urinary and sexual dysfunction and more recently decreased cardiac chronotropic response during exercise, are part
The microbiota–microglia axis in central nervous system disorders
Host microbiota are mostly residing in the gut and contribute to microglial activation states, for example, via short-chain fatty acids
Monocyte markers correlate with immune and neuronal brain changes in REM sleep behavior disorder
The iRBD patients had increased classical monocytes and mature natural killer cells. Remarkably, the levels of expression of Toll-like receptor
Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Animal studies investigating the potential of nutritional interventions on the microbiota–gut–brain axis have led to advancements in our understanding of
Cognitive and Neuropsychiatric Profiles in Idiopathic Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease
Patients diagnosed with iRBD are characterized by poor global cognitive performance, but better long-term memory and higher levels of depression,
MDS research criteria for prodromal Parkinson’s disease
This diagnostic information combines estimates of background risk (from environmental risk factors and genetic findings) and results of diagnostic marker