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Research
Information is knowledge
Information is the most powerful tool in existance and it is my desire to share with our community everything I encounter on my journey to find a solution to Pre-PD and iRBD.
Predicting Parkinson’s Disease Trajectory using Clinical and Neuroimaging Baseline Measures
Predictive biomarkers of Parkinson’s Disease progression are needed to expedite neuroprotective treatment development and facilitate prognoses for patients. This work
Non-negative matrix factorization-based time-frequency feature extraction of voice signal for Parkinson’s disease prediction
The proposed method achieved average classification accuracies of up to 92 % in vowels, and 97 % in words. There
Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation
We found significant alterations in the PD-associated microbiome, which are robust to study-specific technical heterogeneities, although differences in microbiome structure
Genetic Approaches Using Zebrafish to Study the Microbiota–Gut–Brain Axis in Neurological Disorders
The microbiota–gut–brain axis (MGBA) is a bidirectional signaling pathway mediating the interaction of the microbiota, the intestine, and the central
Crosstalk between Gut and Brain in Alzheimer’s Disease: The Role of Gut Microbiota Modulation Strategies
The gut microbiota (GM) represents a diverse and dynamic population of microorganisms and about 100 trillion symbiotic microbial cells that
The Role of Salivary Biomarkers in the Early Diagnosis of Alzheimer’s Disease and Parkinson’s Disease
This review aims to provide an insight into the current literature concerning salivary biomarkers used in the diagnosis of AD
Regional Gray Matter Volume Changes in Parkinson’s Disease with Orthostatic Hypotension
PD patients with OH had more severe autonomic dysfunction and reduction in volume in the right inferior temporal cortex than
CSF Biomarker Flags Parkinson’s Pathology Years Before Symptoms Appear
Real-time quaking-induced conversion (RT-QuIC), a test for pathological misfolded protein, detected alpha-synuclein in the cerebrospinal fluid (CSF) of patients with
Study reveals close link between Parkinson’s disease and certain immune cells in the blood
The researchers have studied a group of patients suffering from REM Sleep Behavior Disorder (RBD), a condition where the patients
Probable REM sleep behavior disorder is associated with longitudinal cortical thinning in Parkinson’s disease
These results support the idea that RBD is an important marker of rapid progression in PD motor and non-motor symptoms
The Aged Intestine: Performance and Rejuvenation
Owing to the growing elderly population, age-related problems are gaining increasing attention from the scientific community. With senescence, the intestine
The Role of Gut Bacterial Metabolites in Brain Development, Aging and Disease
We found significantly altered SCFA levels in patients with autism spectrum disorder (ASD), affective disorders, multiple sclerosis (MS) and Parkinson’s
Gut microbial ecosystem in Parkinson’s disease: New clinico-biological insights from multi-omics
Gut microbial function is altered in PD, characterized by differentially abundant metabolic features that provide important biological insights into gut-brain
Iron homeostasis in host and gut bacteria – a complex interrelationship
Iron deficiency is the most frequent nutritional deficiency in the world with an estimated 1.4 billion people affected. The usual
Cross-seeding of alpha-synuclein aggregation by amyloid fibrils of food proteins
In this work, we investigated the ability of amyloid fibrils derived from two food proteins to heterologously seed the aggregation
The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson’s disease
Interestingly, we found that TCE not only induced LRRK2 kinase activity in the brain, but produced a significant dopaminergic lesion