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Research
Information is knowledge
Information is the most powerful tool in existance and it is my desire to share with our community everything I encounter on my journey to find a solution to Pre-PD and iRBD.
Prophylactic Role of Aloe Components, Butyrate Fermented, Micrnas, and Hyaluronan on Alzheimer’s Disease, Parkinson’s Disease, and Osteoarthritis in Knee Joints
Host microbial cross talk is essential to maintain intestinal homeostasis. However, maladaptation of the response through microbial dysbiosis or defective
Abnormal Gray Matter Volume and Functional Connectivity in Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder
Higher GMV in the cerebellum may be linked with the abnormal motor behaviors during REM sleep in patients with PD-RBD,
Therapeutic uses of natural astaxanthin: An evidence-based review focused on human clinical trials
Author links open overlay panelIn vitro and in vivo studies have associated astaxanthin’s unique molecular features with several health benefits, including
Fecal Microbiota Transplantation Is a Promising Method to Restore Gut Microbiota Dysbiosis and Relieve Neurological Deficits after Traumatic Brain Injury
In conclusion, the current study showed that TBI can induce the gut microbiome dysbiosis and that FMT can rescue gut
Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson’s disease models
Tat-βsyndegron decreased α-synuclein aggregates and microglial activation in an α-synuclein preformed fibril model of spreading synucleinopathy in transgenic mice overexpressing
Lactobacillus plantarum PS128 alleviates neurodegenerative progression in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse models of Parkinson’s disease
PS128 administration also attenuated MPTP-induced oxidative stress and neuroinflammation in the nigrostriatal pathway. Fecal analysis showed that PS128 modulated the
Lactobacillus plantarum PS128 Ameliorated Visceral Hypersensitivity in Rats Through the Gut–Brain Axis
The hypothalamic–pituitary–adrenal axis was modulated by PS128 with decreased corticosterone concentration in serum and the expression of mineralocorticoid receptors in
Microsleep disturbances are associated with noradrenergic dysfunction in Parkinson’s disease
: Sleep microstructure is more severely altered than sleep macrostructure in PDpatients and is associated with widespread dysfunction of the
Associations between probable REM sleep behavior disorder, olfactory disturbance, and clinical symptoms in Parkinson’s disease: A multicenter cross-sectional study
About 33% of the patients with PD had pRBD based on the questionnaires, and both motor and non-motor functions were
Short-chain fatty acids in the context of Parkinson’s disease
Taken together, there is strong evidence that the gastrointestinal microbiome is altered in PD and this is similarly true for
Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study
In patients with IRBD, RT-QuIC detects misfolded α-synuclein in the CSF with both sensitivity and specificity of 90%, and α-synuclein
Smartphone Speech Testing for Symptom Assessment in Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease
We analyzed 4242 smartphone voice recordings collected in clinic and at home from 92 Controls, 112 RBD and 335 PD
Incidence and progression of rapid eye movement behavior disorder in early Parkinson’s disease
RBD and RWA increased significantly over time in PD; time and age were independent factors in a prospective cohort. RBD
Blood Pressure Patterns in Patients with Parkinson’s Disease: A Systematic Review
Patients with Parkinson’s disease have significantly altered blood pressure patterns that carry a negative prognosis. Ambulatory blood pressure monitoring should
Regulation of Mitochondrial Dynamics in Parkinson’s Disease—Is 2-Methoxyestradiol a Missing Piece?
Dysregulation of mitochondrial dynamics may lead to cancers and neurodegeneration; however, the fusion/fission cycle allows mitochondria to adapt to metabolic
Nordic walking in winter as the multitask training in patients with Parkinson’s disease
Winter nordic walking as multitask is the effective measure of exercise treatment in patients with PD, because it improves the