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Research
Information is knowledge
Information is the most powerful tool in existance and it is my desire to share with our community everything I encounter on my journey to find a solution to Pre-PD and iRBD.
A rapid a-synuclein seed assay of Parkinson’s disease CSFpanel shows high diagnostic accuracy
Assays that specifically measure a-synuclein seeding activity inbiological fluids could revolutionize the diagnosis of Parkinson’s disease. Recentimprovements in a-synuclein real-time
A rapid α-synuclein seed assay of Parkinson’s disease CSF panel shows high diagnostic accuracy
Our improved α-synuclein seed amplification assay dramatically reduces the time needed to diagnose Parkinson’s disease while maintaining the high-performance standards
How Your Gut Health Impacts Your Disease Risk
More attention than ever is being put on your gut health, and understandably so, considering a significant proportion of your
Managing the Microbiome – How the Gut Influences Development and Disease
The microbiome lies at the forefront of scientific research, as researchers work to uncover its mysterious influence on human development
The laterodorsal tegmentum is essential for burst firing of ventral tegmental area dopamine neurons
In response to behaviorally salient stimuli, dopamine (DA) neuronsfire in bursts. These data show that the LDTg is critical to
Estimating economic efficiency of preclinical diagnostics of Parkinson disease with cost-utility approach
Neurodegenerative diseases, Parkinson disease among them, set challenges to modern societies both in terms of premature deaths and resources spent
Oxidative Stress in Aging Brain: Nutritional and Pharmacological Interventions for Neurodegenerative Disorders
A large and convincing body of evidence demonstrated that aging is characterized by a progressive decline in the efficiency of
Role of Diet and Nutritional Supplements in Parkinson’s Disease Progression
The goal of this study is to describe modifiable lifestyle variables associated with reduced rate of Parkinson’s disease (PD) progression.
α-Synuclein Responses: Implications for Early Appearance of Sleep Disorders in Parkinson’s Disease
Sleep Disorders (SDs) precede motor symptoms of Parkinson’s disease (PD), suggesting an early effect of disease processes on sleep control
Iron Dysregulation and Inflammagens Related to Oral and Gut Health Are Central to the Development of Parkinson’s Disease
Neuronal lesions in Parkinson’s disease (PD) are commonly associated with α-synuclein (α-Syn)-induced cell damage that are present both in the
Specialist Approaches to Prognostic Counseling in Isolated REM Sleep Behavior Disorder
Most middle-aged and older adult patients with isolated (idiopathic) REM sleep behavior disorder (RBD) eventually develop parkinsonism, dementia with Lewy
Hypomethylation of SNCA in Idiopathic REM Sleep Behavior Disorder Associated With Phenoconversion
Background Hypomethylation of intron 1 of the α‐synuclein (SNCA) gene has been extensively reported in the blood of patients with
Physiological and pathological changes in the enteric nervous system of rotenone-exposed mice as early biomarkers for Parkinson´s disease
Functional changes in PNS and ENS appear early in the course of the disease and are responsible for some of
Copper oxide nanoparticles promote α-synuclein oligomerization and underlying neurotoxicity as a model of Parkinson’s disease
Parkinson’s disease is associated with the formation of protein aggregates called amyloid fibrils. α-synuclein amyloid accumulation is known to be
Gut-Brain Axis in Parkinson’s disease Etiology: The Role of Lipopolysaccharide
Recent studies highlight the initiation of Parkinson’s disease (PD) in the gastrointestinal tract, decades before the manifestations in the central